Procyclidine overdose induced central and peripheral anti-cholinergic toxicity
نویسندگان
چکیده
منابع مشابه
Probing peripheral and central cholinergic system responses.
OBJECTIVE The pharmacological response to drugs that act on the cholinergic system of the iris has been used to predict deficits in central cholinergic functioning due to diseases such as Alzheimer's disease, yet correlations between central and peripheral responses have not been properly studied. This study assessed the effect of normal aging on (1) the tropicamide-induced increase in pupil di...
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Objective(s): Cisplatin-induced peripheral neuropathy is a debilitating side effect in patients receiving this drug. Recent studies suggest hyperbaric oxygen (HBO) therapy as a new treatment approach for models of neural injury. The aim of the current study was to determine the protective effects of HBO preconditioning against peripheral neuropathy induced by Cisplati...
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The nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for their analgesic, anti-inflammatory and antipyretic actions. They are commonly taken in overdose in many areas of the world. The majority of patients with acute NSAID overdose will remain asymptomatic or develop minor self-limiting gastrointestinal symptoms. However, serious clinical sequelae have been reported in patients wit...
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Studies concerning the effects of cholinergic stimulants and blockers on habituation, alternation, classical and instrumental conditioning, differentiation, and discrimination are summarized and discussed. This analysis suggests that many results originally ascribed to associative changes can be more economically accounted for by nonassociative factors inherent in the experiments. Furthermore, ...
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Sarin attacks occurred both in Matsumoto and in Tokyo in 1994-1995; more than 15 people died because of such attacks. The acute toxic effect of Sarin nerve gas (organophosphorus: OP) produces miotic pupils as well as reduced cholinesterase (ChE) activities, which are nicotinic and muscarinic signs. A cholinergic sign may not be the sole mechanism of OP toxicity. Suzuki et al (1) described the f...
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ژورنال
عنوان ژورنال: Toxicology Communications
سال: 2018
ISSN: 2473-4306
DOI: 10.1080/24734306.2018.1459109